Endocrine Abstracts

A 44-year-old female, with non-toxic goiter was referd to our Department for thyroid volume reduction. Serum levels of FT4, FT3 and TSH were within normal range, high resolution ultrasonography show enlarlarged thyroid glands (50 ml), with 2 nodules one in the left and one in the right lobe. Malignancy was ruled out by ultrasound-guided fine-needle aspiration biopsy. Thyroid radioiodine scintigraphy showed homogenous and diffuse uptake in the right lobe, ...

Two female patients aged 44 (PtA) and 68 years old (PtB) with non-toxic nodular goitre for more than 10 years were treated with radioiodine therapy. High resolution ultrasonography show enlarged thyroid glands 50 ml, with two nodules in left and right lobe in PtA and 58 ml with one nodule in the left lobe in PtB. Serum TSH, fT4 and fT3 were in normal ranges. Malignancy was ruled out by ultrasound-guided fine-needle aspiration biopsy. In PtA thyroid radioi...

Radioiodine therapy is non-invasive, safe and cost effective method of therapy for reduction of goitre. We aimed to determine whether radioiodine therapy has benefit effect on the symptoms mimicking hyperthyroidism in nontoxic goitre patients.Material and methods: We studied 20 patients with non toxic nodular goitre, aged 42–79 years, 12 females and 8 males. All the patients complained of some symptoms of hyperthyroidism (palpitation, hot intoleranc...

Most of the patients with the benign cold nodule refuse surgical operation. Radioiodine therapy (RIT) is the choice for these patients. The aim of our study was to evaluate the efficacy of radioiodine therapy to reduce thyroid volume in patients with cold nodule by the use of two doses of radioiodine.Methods: We treated 40 patients with non-toxic nodular goitre with large cold nodule, aged 18 and 48 years; initial 24 h radioiodine uptake (RAIU) was range...

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and prevent evolvement to overt hyperthyroidism.Materials and methods: We treated 1600 patients refered to our department during the last 8 years, aged 23–77 years; 89% of them were females and 11% males; 520 patients with multinodular goitre (MNG), and 1080 patients with au...

Aim: The aim of our study was to evaluate the influence of recombinant human thyroid-stimulating hormone (rhTSH) on the efficacy of radioiodine therapy in patients with non toxic nodular goitre with low RAIU.Materials and methods: The study was performed on 50 patients with non toxic nodular goitre (36 females and 14 males, aged 34–75 years) referred for radioiodine therapy. All patients had low RAIU (8–16%), 24 h after a diagnostic dose of I-1...

We treated 4150 patients, aged 30–70 years; 1950 patient with toxic multinodular goitre (TMNG), and 2200 patient with autonomous toxic nodule (ATN). Qualification of these patients was based on high levels of serum fT3 and fT4, low levels of serum TSH. Malignant changes were excluded in all nodules by fine needle aspiration biopsy. All the patients had serum TSH levels ≤0.1 mU/l and the effective T-half was ≥3 days at the time of treatmen...

Oxidative stress plays an important role in hyperthyroidism-induced tissue damage. We aimed to determine whether radioiodine therapy has benefit effect on the oxidant and antioxidant status in patients with Graves’ Disease.Material and methods: We studied 30 patients with Graves’ disease, aged 18–48 years. 12 normal adult volunteers were studied as control group. All the patients were treated unsuccessfully by antithyroid drugs. The effect...

A young woman aged 23 years, with non-toxic goiter was treated in our Department. Serum levels of FT4, FT3 and TSH were within normal range, high resolution ultrasonography show very large glands (60 ml), with large nodule in left lobe and smaller one in the right lobe. Malignancy was ruled out by ultrasound-guided fine-needle aspiration biopsy. Thyroid radioiodine scintigraphy showed homogenous and diffuse uptake in the right lobe, with very low uptake i...

The aim of our study was to assess the effectiveness of radioiodine therapy (RIT) on the reduction of thyroid volume after pre-treatment adjunct of rhTSH in patients with non-toxic goitre with low RAIU.Material and methods: We treated 36 patients; (28 female, 8 male) aged 35–77 years. Initial 24 h RAIU was ranged between 5 and 17%, and thyroid volume ranged between 42 and 128 ml. Twelve patients had compressive symptoms. Malignant changes were exclu...